Set largely in the dark backwoods just outside of New Orleans, The Skeleton Key stars Hudson as Caroline, a live-in nurse hired to care for an elderly woman's (Rowlands) ailing husband (Hurt) in their home...a foreboding and decrepit mansion in the Louisiana delta. Intrigued by the enigmatic couple and their rambling house, Caroline beings to explore the old mansion. Armed with a skeleton key that unlocks every door, she discovers a hidden attic room that holds a deadly and terrifying secret.
A regular ladies man (McConaughey) bets his friends (Goldberg, Lennon) that he can stay in a relationship for more than 10 days. Unluckily for him, however, the girl (Hudson) that he picks just happens to try to get rid of him almost immediately.